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The compounds of the invention are useful as antibiotics against organisms which are resistant to other tetracycline compounds. Moreover, amino acid substitutions within the α6 helix which, as noted above, forms part of the conserved tetracycline-binding pocket, i.e. Emergency medicine clinics of North America 29 (3): 637–53. - atraso mental por causa de uma malformação durante a gravidez, vasotec 50mg 40mg
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